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These side effects can be reduced by starting with a lower dose and slowly increasing the amount as your body adjusts to the medication

Gastroenterology 1988

In STEP UP, the 7.2 mg dose produced an average weight loss of 20.7% over 72 weeks, compared with 17.5% on 2.4 mg, a difference of about 3 percentage points

Either your body has adapted to GLP-1 receptor activation and side effects have diminished significantly, or you are still experiencing considerable effects that need management

If a patient on Fosamax or another bisphosphonate reports new or worsening thigh pain, this warrants communication with the prescriber