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Binding mode and CCL1 blocking activity of mAb1 The binding of a chemokine to its cognate receptor is most often described by a two-step, two-site model, where the chemokine globular core first engages the receptor N-terminus at CRS1, followed by insertion of the chemokine N-terminus into the orthosteric core of the receptor at CRS2 47,48,49

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Therapeutic potential of NAD-boosting molecules

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