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Depression is a prevalent condition that can strike anyone at any age
Viral nsp12 could alter AA metabolism (especially of the branchedchain amino acids , BCAA), while nsp12, nsp7 , and nsp8 interactions with electron transport chain (ETC) and ribosomal proteins could potentially dysregulate mitochondrial respiration 39
Mechanism studies show that EZH2 promotes ferroptosis by suppressing SLC7A11 , highlighting its diagnostic potential ( 4.3 Evaluation of current clinical evidence Based on current research, three consistent clinical characteristics can be identified: (1) systemic iron metabolism indicators suggest that iron homeostatic imbalance (characterized by iron overload or utilization disorders) is positively correlated with the risk of DKD ( Although multiple ferroptosis-related genes have been identified in DKD, it should be noted that most clinical biomarkers reflect pathway activity rather than direct ferroptotic execution events
