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It is currently being studied in Phase 2 and Phase 3 clinical trials, and any use outside a formal trial setting is considered unlicensed and is not endorsed by NICE or NHS guidance

Conclusion Glutathione Reductase Enzyme gives a Picture for damaged cells due to Oxidative stress during chronic inflammation in Patient with RA and Vitamin C can be considering as approved parameter for oxidative stress due to inflammation respond that will consume by Non- Enzymatic Anti-Oxidant effect

Accordingly, authors highly recommend carnitine supplementation with methotrexate therapy to attenuate or prevent the possible acute kidney injury adverse effect

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