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Previous research has demonstrated that metformin inhibits mitochondrial complex 1 of the electron transport chain 4,41 and activates AMPK 5,6

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The garlic organosulfur compounds were found to effectively reduce dyslipidemia and liver fat by boosting taurine levels and encouraging hepatic fatty acid- oxidation which helps in maintaining healthy glucose levels due to its ability to inhibit DPP-4 and hepatic gluconeogenesis (248)

It confirmed that the dual GIP/GLP-1 mechanism of tirzepatide offers a meaningful clinical advantage over GLP-1-only medications for weight loss