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Nature 653 , 411417 (2026)

The first of these, GCLC-a (Figure 2B), would cleave after position 217, and is an exact match to P4-P1 of nsp5/6, but with an A in P1, a highly favorable residue for that position, although SCoV has a G there, and SCoV2 has an S

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doi: 10.1016/S0140-6736(15)60327-0 Summary Keywords food intake, melanocortin (MC), melanocortin-3 receptor, melanocortin-4 receptor, melanocortin-4 receptor agonist, metabolism, obesity, weight loss Citation Prindle CR, Bennett TL, Rajewski BH, Kelley KJ, Impastato AC, Potterfield R, Marks DL and Delev JY (2026) The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives