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[4] Growth Factor & Gene Expression Studies Investigational applications include: Early growth response gene (EGR-1) expression analysis in cell culture IGF-1/GH signaling pathway interactions in cellular models Anabolic and mitogenic response pathways in muscle and bone cell cultures Matrix metalloproteinase and angiogenic mediator expression studies Laboratory research focuses on EGR-1-mediated transcriptional control of cell growth and repair genes through matrix and angiogenic mediator pathways

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14 A regional lymph node examination should be considered whenever invasive SCC is suspected