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This dual push-pull is why the IGF-1Akt axis is considered a master regulator of muscle mass, although its exact role in the adult muscle response to mechanical load is, by the authors own account, less clearly defined than its role in development and regeneration

The gap between effective and ineffective use comes down to understanding that the dihexa half life dictates dosing frequency, but therapeutic outcomes are determined by what happens at the synaptic level during those brief exposure windows

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