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La rduction de l'indice de mlanine tait statistiquement significative par rapport au placebo dans la majorit des essais, mais les auteurs ont conclu que les limites mthodologiques principalement la petite taille des cohortes et l'absence de donnes long terme ne permettaient pas de considrer l'effet claircissant comme bien tabli

PMID: 2890903

Dose adjustments may be required depending on nutritional status and underlying medical conditions

It will be interesting to understand the functional consequences of these changes, which are relevant for possible application in the development of GLP-1R agonists for medical application in diabetes treatment and for better understanding of the function of these changes in monotreme GLP-1