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The clinical sample collection aspects of this study were approved as human subjects research by the Rhode Island Hospital institutional review board (#1492994), with written informed consent from all participants or their legally authorized representatives for sample collection and data abstraction from medical records

PMCID: PMC4967041

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In addition, NADPH generation via glutamine metabolism in cancer cells supports redox homeostasis by maintaining the cytosolic NADPH pool used to restore oxidized glutathione 29 (Fig