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Dose appears to matter: the effect on drinking in the Lancet trial appeared at the full 2.4 mg dose, while the lower-dose JAMA Psychiatry trial found weaker real-world effects

Semaglutide, originally developed for diabetes management, showed significant weight loss results in both clinical trials and real-world settings, which attracted widespread adoption

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Peak blood concentration occurred between 8 and 72 hours post-injection regardless of location, and the total amount of medication entering the bloodstream was equivalent

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