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5.2 Regulation of macrophage phenotypes by helminths prevents the development of T1D and T2D The possibility that macrophages mediate the beneficial effect of helminths in diabetes emerged from experimental studies using mouse models in which the depletion of T-cells, or the genetic ablation of T-cell signaling molecules, failed to impact the protection from disease elicited by infection with Litomosoides sigmodontis, Heligmosomoides polygyrus , or Schistosoma mansoni (98, 99)

the formation of new blood vessels

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