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In the most apical region of the epithelium there is an intercellular gap (around 90 ) named zonula occludens or tight junctions, followed by the zonula adherens (gap of 200 ), followed by the macula adherens or desmosomes (gap of ~240 ) ( zonula occludens (ZO) family

It is a hormone your intestines release after every meal, a chemical signal between your gut and your brain that says Slow down, youve had enough