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Together with the pharmacodynamic data, this PK knowledge may help in selecting dosing regimens needed to achieve target exposures that maximize efficacy and minimize toxicity, advancing the translation of 7,8-DHF therapy from preclinical to clinical studies

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Definition Box Signal Peptide: A short peptide sequence that triggers downstream cellular responses (gene expression, enzyme activation, cytokine release) by interacting with receptors or transport proteins rather than by being incorporated into larger structures