10.1074/jbc.M116.752261 12 BinieckaM.FoxE.GaoW.NgC
Key points: Gastrointestinal side effects became more common as the dose rose in STEP UP, from 42.8% on placebo to 61.2% on 2.4 mg and 70.8% on 7.2 mg Altered skin sensations, such as tingling, were also more common on 7.2 mg (22.9%) than on 2.4 mg (6.0%) Nausea, diarrhoea, vomiting, and constipation are the most common side effects Side effects are usually worst just after a dose increase and often settle within a few weeks Its worth considering whether increasing the dose is worth the risk of increased side effects
What form of B12 is used in the injection
So it turns out that you can go around the body and there are all of these specific GLP-1 receptor population, that you can see how they tie into the pharmacology
Insulin receptor activation triggers the recruitment of insulin receptor substrate (IRS) proteins, which, when phosphorylated on tyrosine residues, activate PI3K-Akt signaling