The BIOM file output from the DADA2 pipeline and the DECIPHER-aligned FastTree phylogenetic tree were input into QIIME (v1.9.1) and the scripts in the Supplementary Materials (QIIME Scripts compilation) were used to establish the alpha diversity metrics of Chao1 richness estimate, Simpsons evenness measure E, Shannon diversity index H, Simpsons diversity index, and Faiths phylogenetic diversity metric (whole tree) as well as the beta diversity measures of unweighted and weighted UniFrac analyses (the latter of which factors in ASV abundance 37 ) and BrayCurtis dissimilarity analysis
In Phase II results , the highest dose led to 22.5% greater weight loss than placebo after 48 weeks
Furthermore, the inhibitory effect of ZXGD was similar to siHIF-1, suggesting HIF-1, as the core target of ZXGD, has the capability to synergistically regulate multiple therapeutic targets involved in pathological trigger factors for pulmonary vascular remodeling
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