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Acknowledgments Figure 1 was created with BioRender.com

Under the influence of IL-4 and IL-13 and the interactions between adhesion molecules on B cells (class II MHC molecules: CD80/CD86, CD40, and ICAM-1) and T cells (CD3, CD4, CD28, CD40L, and LFA-1 receptors), B cells switch from expressing IgM, IgG2, and IgG3 to IgG4 and IgE (179)

The size can vary from tiny spots to larger patches, and the rash often seems to move around the body, fading in one area and appearing in another

Over 100 mutations have been identified in the SLC22A5 gene resulting in carnitine deficiency, systemic primary