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On the other hand, mice with NLRP3 intact had increased fatigue behavior and increased IL-1 after repeated forced exercise.[ref] In addition to NLRP3 being activated by viral pathogens, it can also be triggered by mitochondrial dysfunction.[ref] This brings us to the next topic of mitochondrial dysfunction in chronic fatigue

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The researchers have tried this in mice and pigs, and both tests were successful, Rajagopalan said