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Precautions and not-recommended situations include history of pancreatitis, severe gastroparesis or other serious gastrointestinal disease, pregnancy/lactation (discontinue before conception), and type 1 diabetes

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[111] treated T2DM patients with exenatide and found that the liver fat content (LFC) of patients decreased from 21.3%19.3% to 12.7%10.6%, a trend that suggested that GLP-1RA drugs could improve liver lipid metabolism

however, shared decision-making between the primary care physician and patient is important for improving patient outcomes