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seven in absentia homolog 2 (SIAH2), a key regulator, together with hypoxia-inducible factor 1 alpha (HIF-1), of the cellular hypoxic responses under pathological conditions such as ischemia-reperfusion, whose association with NRF2 causes the degradation of NRF2 irrespective of its phosphorylation status [230]

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PREECLAMPSIA Walsh and Wang 26 determined that GSH peroxidase activity is significantly lower, and lipid peroxides and thromboxane significantly higher, in preeclamptic placentas than in healthy placentas because of an unknown mechanism

10.3906/vet-0805-11 36