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Neuron 62 , 670682 (2009)

Under 21 CFR 312.120, sponsors can use GCP-compliant foreign clinical trial results to support an IND submissionreducing costs, saving years of development time, and accelerating U.S

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In this model, myostatin induced down regulation of Akt, p70S6 kinase and FoxO1 phosphorylation can be restored by treatment with IGF-I, suggesting that IGF-I/Akt signaling is dominant over inhibition of the myostatin/Smad/Akt pathway [57]