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Purified complex was resolved as a monodisperse peak on SEC, with all components of the complex identified in SDS-PAGE of the SEC peak (Supplementary Fig

IGF-IR promotes tumor growth, anoikis evasion, and metastasis PI3K is a classical lipid kinase that catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P 3 ) [44]

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Based on typical FDA review timelines and the current progress of trials, analysts project: Phase 3 trial completion: Late 2025 to early 2026 FDA submission: First half of 2026 Potential FDA approval: Q3 2026 to Q1 2027 Commercial availability: 2-3 months post-approval The FDA has not granted any special designations (Breakthrough Therapy, Fast Track) for Retatrutides obesity indication, which may mean standard review timelines apply