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We noted a progressive weight loss in both DIO and ob/ob mice treated with SLU-PP-332 (Supplemental Fig

Self-administered B12 shots are generally recommended for individuals: whose bloodwork has documented low B12 levels Patients with pernicious anemia or a lack of intrinsic factor Individuals with Crohn's disease, celiac disease, or post-bariatric surgery malabsorption Vegans and strict vegetarians are unable to correct the deficiency through diet Older adults whose stomach acid production has declined with age Anyone on long-term metformin or proton pump inhibitors Across most of the U.S., injectable B12 is not sold over the counter a clinician has to write the script before a pharmacy can dispense it

The company primarily provides care through brick-and-mortar clinics, not telehealth.

Athletes subject to WADA, USADA, NCAA, or other sport-governing-body testing should not use it

doi: 10.1007/S00125-025-06462-Y 241 Evans-MolinaCDorYLernmarkMathieuCMillmanJRMirmiraRGet al