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Signaling and distribution of the GHSR1a The GHSR1a was first identified in 1996 by a team of researchers who were looking for a way to improve growth hormone release (Howard et al., 1996), and this discovery was followed by the identification of its natural ligand, ghrelin, a peptide hormone produced by the stomach (Kojima et al., 1999)

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DMPs associated with MAPK and mTOR signaling pathways were extracted for Gene set enrichment analysis (GSEA) using the clusterProfiler package, based on log-fold changes aggregated at the gene level from DMP results