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Comparison with other GLP-1 medications *Yellow Card reporting data based on MHRA Yellow Card scheme trend analysis and may not reflect exact current figures Key points: Headache frequency on Mounjaro About 1 in 12 UK patients experience headaches on Mounjaro Headache rates are similar to placebo in clinical trials Headaches are less common than digestive side effects Most headaches are temporary, lasting 2-4 weeks Mounjaro has slightly lower headache rates than other GLP-1 medications Preventing Mounjaro-related headaches You can take several proactive steps to reduce your risk of developing headaches while taking Mounjaro: Hydration strategies Water intake is critical for preventing Mounjaro-related headaches