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Treasure Island (FL): StatPearls Publishing
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The principal hallmarks of senescence are an increase in senescence-associated galactosidase activity (SA- Gal), the presence of telomere dysfunction-induced foci (TIF), upregulation of specific cell cycle regulators (mainly the p53-p21 and p16-pRb axes), altered gene expression patterns, and the activation of a senescence-associated secretory phenotype (SASP), implying the synthesis and secretion of inflammatory mediators, growth factors, and extracellular matrix proteins [270,271]
Yuan Q, Tang B, Zhang C
Alpha-lipoic acid and CoQ10 also enhance redox cycling
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