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Covariates Data on covariates were obtained using ICD-8 (19771993) and ICD-10 (19932018) codes ( Supplemental Table S2 ), ATC codes (19952018) ( Supplemental Table S3 ), or a combination of both ( Supplemental Table S4 )

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Data and materials availability Upon request, and subject to certain criteria, conditions, and exceptions (see for more information), Pfizer will provide access to individual de-identified participant data from Pfizer-sponsored global interventional clinical studies conducted for medicines, vaccines and medical devices (1) for indications that have been approved in the US and/or EU or (2) in programs that have been terminated (i.e., development for all indications has been discontinued)