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Targeting the incretin/glucagon system with agonists Figure 1: Schematic representation of the effects of multi-agonists targeting the receptors for GLP-1/Glucagon, GLP-1/GIP and GLP-1/GIP/Glucagon [28] In Part I of our blog we reported on dual receptor agonists targeting the incretin/glucagon system to treat obesity and type 2 diabetes mellitus with high efficacy

The retatrutide group showed an average weight loss of 8.96 kg (or 10% of their body weight)

another method tried was addition of polyethylene glycol (PEG) to form PEGylated GLP-1

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