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A 2021 study published in The Lancet found that while GLP-1 drugs were effective for many, their success varied based on factors such as genetic predisposition, underlying medical conditions, and adherence to lifestyle modifications

Trial protocols and community sources typically pair treatment with resistance training to support muscle retention

In addition, these results were significantly better when compared to the weight-loss achieved using orlistat (Xenical or alli)

These medicines can have a lot of side effects, including making people not hungry to the point that they dont get enough calories and may experience vitamin deficiencies and lose lean body mass, including muscle

In other words, lowering your set point weight will increase the likelihood youll be able to keep the weight off