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Existing treatment strategies primarily rely on lifestyle modifications, such as exercise and dietary restrictions, as the sole validated therapeutic intervention

Prolactin levels should be considered if low testosterone is present or if symptoms suggest pituitary dysfunction

This article summarises available evidence, highlights gaps and proposes practical approaches for safe, effective switching

GLP-1 exerts anti-inflammatory effects by suppressing the NF-B signaling pathway, which leads to a decrease in the production of pro-inflammatory cytokines like TNF- and IL-6, thereby mitigating liver inflammation and fibrosis

In terms of average weight loss and blood sugar reduction in clinical trials, yes tirzepatide consistently outperforms semaglutide