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J Biochem Biophys 3 , 102114 (2021)

& Ganesh, K

One possible mechanism would be GLP-1R-mediated activation of the vagus nerve which projects to the nucleus of the solitary tract

Methotrexate-induced liver enzyme elevations often resolve with temporary withdrawal or folic acid supplementation, which mitigates hepatic toxicity without compromising efficacy (Balak et al