Assuming that the percentage of patients showing an increase in serum vitamin B12 concentration to above 179 pg/ml in both groups is 70%, means the study requires at least 304 patients (152 in each arm) for a threshold of non-inferiority of 10% and a statistical power of 60% with significance set at p 179 pg/ml: patient preference questionnaire Randomisation of patients to treatment group Visit 1 (start of treatment) Anamnesis: record whether the patient lives alone or with others, lifestyle habits, use of alcohol, whether a vegan diet is followed, whether the patient has undergone gastrectomy Symptoms: record paresthesia, asthenia, loss or reduction of appetite, sadness or change in state of mind, concomitant pharmacological treatment Physical examination: for Hunters glositis, positional and vibrational sensitivity Questionnaires: Lobo cognitive mini-exam, EuroQoL-5D Record concomitant treatment Request analyses to be performed one week before next visit: haemogram and serum vitamin B12 Therapeutic plan: patient in oral arm provision of medication

There is no single BPC-157 dosage that applies to every patient
Some people feel their best with weekly shots, especially if they have a demanding lifestyle, while others find a monthly visit is perfect for maintaining their energy levels and mental clarity
The idea is that this peptide works by tapping into the body's fundamental repair processes, essentially giving your natural healing abilities a significant push in the right direction
Homocysteine and methylmalonic acid levels in the blood are stronger indicators of proper vitamin B12 activity than homocysteine