Sbihi H, Boutin RC, Cutler C, Suen M, Finlay BB, Turvey SE
Currently on FDA Category 2 with a PCAC review scheduled for July 2026
Recent findings suggest pairing with 5-Amino-1MQ sustains NAD+ longer, as it inhibits NAD+-consuming enzymes, potentially extending therapeutic effects.[8] Understanding 5-Amino-1MQ: A Molecule That Helps Preserve NAD+ What Is 5-Amino-1MQ
GLAST and GLT-1 act as Glu transporters in glial cells in vivo and are involved in the regulation of Glu concentration in synaptic clefts, whereas EAAC1 is not involved in the regulation of extracellular Glu levels in synaptic clefts, but rather in the regulation of GSH production via extracellular Cys uptake
They are also potential candidates for peptidomimetics for studying protein-protein, protein-peptide, and peptide-peptide interactions