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Microglia-derived ASC specks cross-seed amyloid- in Alzheimers disease

While these medications are highly effective, GLP-1 side effectsespecially gastrointestinal issuescan lead to early discontinuation if not properly addressed

Studies demonstrate that semaglutide and tirzepatide reduce HbA1c by 1-2 percentage points in lean diabetic patients, with additional benefits for blood pressure and cholesterol

Furthermore, malfunction of the GDH pathway has been implicated in several other human diseases including diabetes [109,110,111], neurodegenerative disorders [112], as well as congenital syndromes that affect mainly children [113]

Therapeutic Targets of Brain Insulin Resistance in Sporadic Alzheimers Disease