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Amylin/Pramlintide Combinations Previous animal studies have shown that amylin treatment significantly enhanced hypothalamic anorexigenic leptin signaling, while the combination treatment with amylin and leptin led to marked, synergistic reductions in food intake (up to 45%) and fat-specific weight loss (up to 15%)

Given that waist circumference independently predicts cardiovascular events beyond BMI alone, this specific measurement carries clinical significance

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[10] [12] A GP or specialist can advise on eligibility and the most suitable treatment based on individual clinical circumstances

Mean and SD