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10.1016/j.lfs.2005.09.040

Sensitivity analyses using MR-Egger, weighted median, weighted mode, simple mode, maximum likelihood, and RAPS (Supplementary Table S4) showed consistent directionality of effects for schizophrenia, anxiety disorders, and autism

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Improvements plateau at a new baseline after about 6 months of consistent use

A Mayo Clinic study in The Lancet [1] (2025) followed 400 postmenopausal women on tirzepatide for 12+ months: HRT + tirzepatide: 17% total body weight loss Tirzepatide alone: 14% or 35% less 45% of HRT users achieved 20% weight loss vs