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IL-10 has negative immunoregulatory activities by inhibiting the production of M1 macrophage and T helper (Th)-1 cytokines, dendritic cells stimulating CD4 + T cells and Th-2 responses, and attenuates CD8 +, M1 macrophage, and Th-1 and Th-2 associated immunopathology (43, 44)

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Other than GI-related side effects, patients on semaglutide also report serious side effects, such as kidney problems, pancreatitis, gallbladder disease, hypoglycemia (low blood sugar), and severe allergic reactions