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The method of any one of embodiments 118-138, wherein the composition is free or substantially free of water, C1-C6 alcohols or C1-C6 glycols, C1-C4 alcohols or C1-C4 glycols, or any combination thereof

Since the cellular synthesis of glutathione is ATP-dependent, decreased ETC activity also undermines glutathione synthesis, further exacerbating oxidative stress in a vicious cycle [8]

Interestingly, SIRT1 deficiency in MDSCs promotes a switch to the M1 lineage, reducing their immunosuppressive capacity and promoting a pro-inflammatory phenotype associated with attacking tumor cells

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2) is mediated by the organic anion transporters 1 (OAT1