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Semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2

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Its compact tripeptide structure ensures rapid diffusion into fibroblast, keratinocyte, and endothelial models, while its copper chelate enables robust activation of lysyl oxidase and superoxide dismutase

In some embodiments, the gel is a solvent release gel such that the desired gel properties are formed after administration to or near the targeted auris structure, that is, as the solvent in the injected gel formulation diffuses out the gel, a gel having the desired gel properties is formed