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Doxycycline remains the first-line treatment for Lyme disease, but knowing when to start treatment after a tick bite requires understanding specific timelines and risk factors

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Indoxyl sulfate induces myotube atrophy by ROS-ERK and JNK-MAFbx cascades

Corroborating this pathogenic axis, recent studies using cortical neurons derived from patient induced pluripotent stem cells (iPSCs) have demonstrated that presenilin-1 mutations (F105C and A246E) induce pronounced mitochondrial defects, which are remarkably rescued by amyloid precursor protein (APP) knockout, identifying APP as a critical bridging mediator of familial AD-associated mitochondrial dysfunction [45]

PHENIX: a comprehensive Python-based system for macromolecular structure solution