The salt forms are different active ingredients than is used the approved drugs, which contain the base form of semaglutide
The industrys problem is that decades of product hopping strategies based on marginal reformulations dosing frequency changes, salt modifications, device tweaks have trained payers to be skeptical of clinical differentiation claims
Different tissues may respond differently to metformin treatment, and the optimal dosage may vary for different individuals or medical conditions
doi: 10.1096/fj.02-0881fje 142
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