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doi: 10.1038/s41598-021-81628-3 187 ZengX.TangS.DongX.DongM.ShaoR.LiuR.et al

Nicotinamide Nucleotide Transhydrogenase (NNT) mutations are responsible for the development of FGD

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In rats, SM-130686 was found to enhance GH secretion and body weight gain.20 Another non-peptidyl GHS, ibutamoren mesylate (MK-677), was reported to stimulate the release of GH and to show an oral bioavailability of more than 60%.4, 18 Oral administration of MK-677 was also shown to elevate GH levels, as well as IGF-I and cortisol levels, in dogs6 and that this stimulatory effect is dependent on the presence of an intact pituitary.7 In humans, daily oral administration of MK-677 in healthy older adults,8 GH-deficient adults,9 or GH-deficient children10 increases serum GH, IGF-I, and IGFBP-3 concentrations, suggesting that these GHSs are potential treatments for growth disorders

& Kakizaki, H