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However, when making decisions for reimbursement and setting premiums, health insurers need to balance such long-term policyholder health improvements against short- to medium-term increases in claims expenditure

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The risk of intestinal blockage is highest after using the medication for one and a half years, which is longer than most clinical trials for these types of drugs

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doi: 10.1523/JNEUROSCI.3863-05.2006