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DAG-mediated activation of PKC regulates diverse cellular processes such as cell growth, differentiation, and apoptosis

It also reduced pro-apoptotic protein Bax and increased Bcl-2 levels, thereby limiting mucosal cell apoptosis and improving overall tissue regeneration

In addition, some of the absorption will be metabolized by the liver before reaching circulation (first-pass effect)

As an example, miR-378 and miR-132 have been shown to increase the survival of luteal cells and progesterone synthesis by targeting pro-apoptotic genes and increasing the expression of STAR, respectively (104)

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