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Moreover, in a dose-dependent manner, TNF- inhibited the myogenic development of human urethral rhabdosphincter cells via the phosphoinositide 3-kinase (PI3K) and p38-mitogen-activated protein kinase (MAPK) pathways, indicating that TNF- could be a risk factor for SUI in elderly individuals (Shinohara et al

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Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells (Stockwell, 2022)

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