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Impact oftreatment with iron chelators in lower-risk MDS patients participating in the European Leukemianet MDS (EUMDS) registry

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Pathways of note that have been shown to promote OPC differentiation through cannabinoid receptors are the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) and mammalian target of rapamycin (mTOR), ERK/MAPK, and Rat sarcoma (Ras) homolog family member A/Rho-associated protein kinase (RhoA/ROCK