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Acknowledgements This work was supported by the Intramural Research Program of the NIH/National Institute of Environmental Health Sciences 1Z01ES090079

doi: 10.3389/fpsyt.2018.00589 214 KatafuchiTKondoTTakeSYoshimuraM

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Some portion of intranasally administered peptides may reach the brain through the olfactory pathway, bypassing the blood-brain barrier that limits systemic delivery to CNS tissues