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Methods In the PIONEER trials, people with type 2 diabetes were randomised to orally administered semaglutide versus placebo (PIONEER 1, 4, 5 and 8), empagliflozin (PIONEER 2), sitagliptin (PIONEER 3) and liraglutide (PIONEER 4) for 2678 weeks

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Even at low doses, Ag NPs have been shown to changes in metabolism, modulate oxidative stress-related gene expression, and interfere with the cell cycle, particularly in human skin fibroblasts