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Women of childbearing age should use contraception while on tirzepatide and discontinue the medication at least 2 months before attempting conception to allow complete washout given the long half-life

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This observed relation between low vitamin B-12 concentrations in pregnancy and child insulin resistance was also supported by data from Nepal, but supplementation of pregnant women with vitamin B-12containing micronutrients was not found to affect child HOMA-IR (40)

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