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Consequently, intracellular zinc homeostasis alterations regulate downstream molecular objectives, in addition to protein kinase C (PKC), ERK1/2 activation leading to neuronal cell death, cAMP-dependent protein kinase (PKA), Ca/calmodulin-dependent protein kinase II (CaMKII), phosphodiesterases (PDEs), protein tyrosine phosphatases (PTPs), and transcription factors, such as NF-B

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Two identical Phase III studies, TRONTIER 1 and 2, are underway to evaluate the efficacy and safety in people with early symptomatic Alzheimers disease

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(Stefanello et al., 2009)